Ionization Potentials of Nucleic Acid Intercalators

Synthesis of Monomeric Acridine Derived Nucleic Acid Intercalators

The blood supply in industrialized countries is safer than ever. However, blood is a natural vehicle for the transmission of infectious agents. In recent years, numerous pathogens have emerged in Europe, the United States and worldwide with the potential to affect the safety of the blood supply. Although the movement of transfusable blood and blood components between countries is relatively unc...

Synthesis of Dimeric Acridine Derived Nucleic Acid Intercalators

A series of antiviral compounds consisting of an intercalating acridine derived part, a spacer region and a reactive EDTA-derived conjugate was synthesized in an easy sequence. Suitably monoprotected 1,ω-alkyldiamines gave upon reaction with 6,9-dichloro-2-methoxyacridine (1) followed by deprotection and reaction with EDTA dianhydride the target molecules. In the presence of ascorbate a reducti...

The nucleic acid of African Horse-Sickness Virus

Electronic structure and spectroscopy of nucleic acid bases: ionization energies, ionization-induced structural changes, and photoelectron spectra.

We report high-level ab initio calculations and single-photon ionization mass spectrometry study of ionization of adenine (A), thymine (T), cytosine (C), and guanine (G). For thymine and adenine, only the lowest-energy tautomers were considered, whereas for cytosine and guanine we characterized the five lowest-energy tautomeric forms. The first adiabatic and several vertical ionization energies...

Theory of ionization potentials of nonmetallic solids

Yu Kumagai,1,2,* Keith T. Butler,3 Aron Walsh,3,4 and Fumiyasu Oba1,5,6 1Materials Research Center for Element Strategy, Tokyo Institute of Technology, Yokohama 226-8503, Japan 2PRESTO, Japan Science and Technology Agency, Tokyo 113-8656, Japan 3Centre for Sustainable Chemical Technologies and Department of Chemistry, University of Bath, Bath BA2 7AY, United Kingdom 4Department of Materials, Im...